Guanosine Diphosphate

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Rho/Rac guanine nucleotide exchange factor 2 ; Homo sapiens







42 Article(s)
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1 30979377 NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells. 2019 Apr 12 1
2 30062412 High-Throughput Assay for RhoGEFs Based on the Transcreener® GDP Assay. 2018 4
3 29106825 Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype. 2017 Nov 2 1
4 27458535 Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies. 2016 Jun 1
5 27558716 Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity. 2016 Aug 23 1
6 25319541 The G protein α chaperone Ric-8 as a potential therapeutic target. 2015 Jan 1
7 25480567 Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3). 2015 Mar 2
8 25825487 Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. 2015 May 15 1
9 26195453 A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP Assay. 2015 Dec 4
10 24520163 Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation. 2014 Feb 11 1
11 24597981 Amplification of B cell receptor-Erk signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia. 2014 Dec 2
12 24853419 Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice. 2014 May 22 1
13 22960035 Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras. 2013 Jan 2
14 21390270 Nucleotide binding switches the information flow in ras GTPases. 2011 Mar 3
15 21494904 Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a. 2011 Apr 1
16 21828055 Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation. 2011 Oct 21 1
17 19942850 Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. 2010 Jan 20 2
18 19356586 Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42. 2009 Mar 27 1
19 19745154 Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. 2009 Sep 11 2
20 18505730 Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. 2008 Aug 8 3
21 18562321 Guanine nucleotide exchange factor independence of the G-protein eEF1A through novel mutant forms and biochemical properties. 2008 Aug 22 1
22 16257999 GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. 2006 Mar 1
23 16472645 Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b. 2006 1
24 15709769 Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model. 2005 Feb 22 4
25 15850775 Novel intermediate of Rac GTPase activation by guanine nucleotide exchange factor. 2005 Jun 3 7
26 16248653 Common semiopen conformations of Mg2+-free Ras, Rho, Rab, Arf, and Ran proteins combined with GDP and their similarity with GEF-bound forms. 2005 Nov 2 2
27 14597635 Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. 2004 Jan 30 1
28 14625275 Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase. 2004 Feb 6 1
29 15544329 Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains. 2004 Nov 23 1
30 12680752 Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. 2003 Apr 15 1
31 14654833 Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor. 2003 Dec 4 1
32 10843989 The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins. 2000 Aug 18 2
33 9763446 Identification of regulators for Ypt1 GTPase nucleotide cycling. 1998 Oct 1
34 9843686 Nuclear transport factor p10/NTF2 functions as a Ran-GDP dissociation inhibitor (Ran-GDI). 1998 Dec 3 1
35 9857026 Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. 1998 Dec 25 1
36 9132016 Structural and functional analysis of a mutant Ras protein that is insensitive to nitric oxide activation. 1997 Mar 25 1
37 7581745 Translational control of eukaryotic gene expression. Role of the guanine nucleotide exchange factor and chain initiation factor-2. 1994-1995 2
38 8049218 Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange. 1994 Aug 9 2
39 1772451 Re-evaluation of rate constants involved in the action of the initiation and elongation factors eIF-2B and EF-Ts. 1991 Sep 2
40 2229078 Purification and characterization of sea urchin initiation factor 2. The requirement of guanine nucleotide exchange factor for the release of eukaryotic polypeptide chain initiation factor 2-bound GDP. 1990 Nov 5 1
41 3947361 Purification and properties of the guanine nucleotide exchange factor (GEF) from HeLa cells and its role in the initiation of protein synthesis. 1986 Feb 13 3
42 6320181 Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2. 1984 Jan 22