Pub. Date : 2005 Feb 22
PMID : 15709769
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein we have examined in detail the catalyzed GDP/GTP exchange reaction mechanism by a Ras specific GEF, GRF1. | Guanosine Diphosphate | Rho/Rac guanine nucleotide exchange factor 2 | Homo sapiens |
| 2 | The release of the Ras-bound GDP was dependent upon the concentration and the structure of the incoming nucleotide, in particular, the hydrophobicity of the beta and gamma phosphate groups, suggesting that the GTP binding step is a prerequisite for GDP dissociation, is the rate-limiting step in the GEF reaction, or both. | Guanosine Diphosphate | Rho/Rac guanine nucleotide exchange factor 2 | Homo sapiens |
| 3 | The release of the Ras-bound GDP was dependent upon the concentration and the structure of the incoming nucleotide, in particular, the hydrophobicity of the beta and gamma phosphate groups, suggesting that the GTP binding step is a prerequisite for GDP dissociation, is the rate-limiting step in the GEF reaction, or both. | Guanosine Diphosphate | Rho/Rac guanine nucleotide exchange factor 2 | Homo sapiens |
| 4 | These results strongly support a GEF reaction mechanism by which nucleotide exchange occurs on Ras through a direct GTP/GDP displacement model. | Guanosine Diphosphate | Rho/Rac guanine nucleotide exchange factor 2 | Homo sapiens |