Title : Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Pub. Date : 2004 Jan 30

PMID : 14597635






1 Functional Relationships(s)
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1 Based on the available structural information, we have identified the highly conserved amino acid pairing of Asn(1406)Trio-Asp(65)Rac1 of the GEF-Rho GTPase interaction as the critical catalytic machinery required for the Rac1 GDP/GTP exchange reaction. Guanosine Diphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens