Doxorubicin

TNF superfamily member 10 ; Homo sapiens







102 Article(s)
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51 17893044 Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. 2007 Nov 1 4
52 17922852 Low concentrations of doxorubicin sensitizes human solid cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor (R) 2-mediated apoptosis by inducing TRAIL-R2 expression. 2007 Dec 2
53 18006836 Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death. 2007 Nov 15 2
54 16327988 Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. 2006 Jan 1
55 16428504 Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death. 2006 Jan 15 2
56 16619517 C-jun N-terminal kinase activation is required for apoptotic cell death induced by TNF-related apoptosis-inducing ligand plus DNA-damaging agents in sarcoma cell lines. 2006 Mar-Apr 2
57 16923369 [Role of caspase-8 and DR5 in TRAIL-induced apoptosis of neuroblastoma cells]. 2006 Aug 1
58 17047073 Tumor necrosis factor-related apoptosis-inducing ligand is required for tumor necrosis factor alpha-mediated sensitization of human breast cancer cells to chemotherapy. 2006 Oct 15 2
59 17106251 Targeting the short form of cFLIP by RNA interference is sufficient to enhance TRAIL sensitivity in PC3 prostate carcinoma cells. 2006 Dec 2
60 15781649 Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. 2005 Mar 15 1
61 15809718 Expression of TNF-related apoptosis-inducing ligand in human hepatocellular carcinoma. 2005 May 1
62 15897917 Subtoxic concentration of doxorubicin enhances TRAIL-induced apoptosis in human prostate cancer cell line LNCaP. 2005 6
63 16098063 Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. 2005 Aug 1
64 15067350 Sensitivity of fresh isolates of soft tissue sarcoma, osteosarcoma and giant cell tumour cells to Apo2L/TRAIL and doxorubicin. 2004 May 4
65 15110186 TRAIL and chemotherapeutic drugs in cancer therapy. 2004 1
66 15289869 Doxorubicin potentiates TRAIL cytotoxicity and apoptosis and can overcome TRAIL-resistance in rhabdomyosarcoma cells. 2004 Sep 6
67 15329202 [Tumor necrosis factor related apoptosis-inducing ligand induces apoptosis and sensitizes resistant hepatic cancer cells to chemotherapy]. 2004 Aug 2
68 12584736 Enhancement of TRAIL/Apo2L-mediated apoptosis by adriamycin through inducing DR4 and DR5 in renal cell carcinoma cells. 2003 Apr 20 2
69 12610517 A mechanism of resistance to TRAIL/Apo2L-induced apoptosis of newly established glioma cell line and sensitisation to TRAIL by genotoxic agents. 2003 Jan 27 1
70 12660816 Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. 2003 Mar 27 1
71 12763223 Trail-induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines. 2003 Jun 9
72 12800232 Synergistic antitumor effect of TRAIL and doxorubicin on colon cancer cell line SW480. 2003 Jun 5
73 12835727 Ex vivo purging of leukemia cells using tumor-necrosis-factor-related apoptosis-inducing ligand in hematopoietic stem cell transplantation. 2003 Jul 11
74 12838325 Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. 2003 Jul 7 2
75 12904602 TRAIL/Apo2L ligands induce apoptosis in malignant rhabdoid tumor cell lines. 2003 Nov 4
76 12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. 2003 Sep 1
77 12926060 Retrovirus-mediated transduction of TRAIL and chemotherapeutic agents co-operatively induce apoptotic cell death in both sarcoma and myeloma cells. 2003 Jul-Aug 2
78 12946317 Combination of TRAIL gene therapy and chemotherapy enhances antitumor and antimetastasis effects in chemosensitive and chemoresistant breast cancers. 2003 Sep 2
79 14500373 Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. 2003 Sep 1 4
80 14601052 Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells. 2003 Dec 20 4
81 15033719 Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8. 2003 Dec 4
82 11803469 TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. 2002 Jan 10 1
83 11857034 Resistance of prostate cancer cells to soluble TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL. 2002 Feb 3
84 11956588 Doxorubicin enhances TRAIL-induced apoptosis in prostate cancer. 2002 May 7
85 11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. 2002 Jun 1 8
86 12014636 Chemosensitization of T-47D breast carcinoma cells to TRAIL and Fas receptor-induced killing. 2002 Mar-Apr 1
87 12398939 Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis. 2002 Oct 3
88 12439752 Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells. 2002 Nov 14 1
89 12496481 Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression. 2002 Sep-Oct 6
90 11245478 Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. 2001 Feb 15 1
91 11417478 In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity. 2001 Jun 5
92 11468181 TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. 2001 Aug 1 8
93 11472983 Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines. 2001 Jul 2
94 11751478 Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis. 2001 Dec 7
95 11772267 Concepts in the use of TRAIL/Apo2L: an emerging biotherapy for myeloma and other neoplasias. 2001 Aug 2
96 12118126 Enhanced apoptosis of soft tissue sarcoma cells with chemotherapy: A potential new approach using TRAIL. 2001 Dec 1
97 10690508 Molecular determinants of response to TRAIL in killing of normal and cancer cells. 2000 Feb 4
98 10933923 The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. 2000 Feb 1
99 10960439 Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines. 2000 Sep 1
100 11090076 Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. 2000 Dec 1 2