Title : Synergistic antitumor effect of TRAIL and doxorubicin on colon cancer cell line SW480.

Pub. Date : 2003 Jun

PMID : 12800232






5 Functional Relationships(s)
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1 The present study was to investigate the cell killing action of TRAIL on colon cancer cell line SW480, its synergistic effect with doxorubicin, and the possible mechanisms. Doxorubicin TNF superfamily member 10 Homo sapiens
2 (3) TRAIL could synergize with doxorubicin to kill SW480 cells effectively, which was represented by the boosted killing effect of doxorubicin on theses cells. Doxorubicin TNF superfamily member 10 Homo sapiens
3 (3) TRAIL could synergize with doxorubicin to kill SW480 cells effectively, which was represented by the boosted killing effect of doxorubicin on theses cells. Doxorubicin TNF superfamily member 10 Homo sapiens
4 IC(50) of doxorubicin against SW480 cells sharply reduced when it was combined with TRAIL. Doxorubicin TNF superfamily member 10 Homo sapiens
5 CONCLUSION: SW480 cells are not sensitive to TRAIL, but TRAIL can synergize with lower concentration of doxorubicin to induce apoptosis effectively. Doxorubicin TNF superfamily member 10 Homo sapiens