Cisplatin

heat shock protein 90 alpha family class A member 1 ; Homo sapiens







42 Article(s)
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1 34637110 Cisplatin-based Electrochemotherapy Significantly Downregulates Key Heat Shock Proteins in MDA-MB-231-Human Triple-Negative Breast Cancer Cells. 2022 Jan 1
2 35190872 Hsp90 inhibition sensitizes DLBCL cells to cisplatin. 2022 Apr 3
3 33331136 HSP90 identified by a proteomic approach as druggable target to reverse platinum resistance in ovarian cancer. 2021 Apr 3
4 33738259 Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovarian Cancer via AKT/GSK3β/β-Catenin Signaling. 2021 3
5 34585447 Zeylenone synergizes with cisplatin in osteosarcoma by enhancing DNA damage, apoptosis, and necrosis via the Hsp90/AKT/GSK3β and Fanconi anaemia pathway. 2021 Oct 2
6 34944784 HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells. 2021 Dec 7 2
7 32608202 Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells. 2020 Jul 2
8 33102211 Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib. 2020 6
9 33167494 Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors. 2020 Nov 5 2
10 30925862 PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma. 2019 Mar 29 2
11 31449053 Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation. 2019 Oct 1 1
12 29331417 Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma. 2018 Apr 1 1
13 30153855 HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma. 2018 Aug 28 1
14 27887849 Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4'fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells. 2017 Jan 1
15 28288818 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways. 2017 Jul 1 1
16 26481477 Membrane-bound heat shock proteins facilitate the uptake of dying cells and cross-presentation of cellular antigen. 2016 Jan 1
17 25333998 Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells. 2015 Jan 2
18 26221207 Reversing drug resistance of cisplatin by hsp90 inhibitors in human ovarian cancer cells. 2015 2
19 26517240 Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition. 2015 Dec 29 2
20 24317439 The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway. 2014 Feb 4
21 23135731 Regulation of survival and chemoresistance by HSP90AA1 in ovarian cancer SKOV3 cells. 2013 Jan 5
22 23561390 Re: potential role of hsp90 inhibitors in overcoming Cisplatin resistance of bladder cancer-initiating cells. 2013 Apr 1
23 21864883 Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions. 2012 Apr 3
24 21964864 Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells. 2012 Aug 15 6
25 22537224 Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. 2012 Apr 26 4
26 20883729 HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion. 2011 Jan 1
27 21645448 [The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line]. 2011 Jun 4
28 18992762 The dimethylthiourea-induced attenuation of cisplatin nephrotoxicity is associated with the augmented induction of heat shock proteins. 2009 Jan 15 1
29 19578756 Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses. 2009 Aug 1
30 19740745 A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. 2009 Nov 6 1
31 18279962 Defining targets of modulation of human tumor cell response to cisplatin. 2008 Jul 1
32 18955054 Cisplatin differently affects amino terminal and carboxyl terminal domains of HSP90. 2008 Nov 26 6
33 17319785 Hsp90 inhibitor geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin. 2007 1
34 21122290 [Different proteome of human lung adenocarcinoma cells treated with NS-398 and cisplation]. 2007 Aug 20 1
35 17073714 Effectiveness of hsp90 inhibitors as anti-cancer drugs. 2006 Oct 1
36 15455381 Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. 2005 Jan 10 1
37 16273226 Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin. 2005 Dec 3
38 15378690 A proteomic approach to cisplatin resistance in the cervix squamous cell carcinoma cell line A431. 2004 Oct 1
39 12842893 Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. 2003 Sep 12 1
40 12869591 The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. 2003 Oct 5
41 11751878 A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket. 2002 Mar 1 3
42 12415202 Heat-shock protein 90: potential involvement in the pathogenesis of malignancy and pharmacological intervention. 2002 Oct 1