Pub. Date : 2008 Nov 26
PMID : 18955054
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cisplatin differently affects amino terminal and carboxyl terminal domains of HSP90. | Cisplatin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | We previously demonstrated that the antineoplastic reagent, cisplatin, inhibits the aggregation prevention activity of mammalian HSP90. | Cisplatin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | We now show that cisplatin binds both the amino terminal and carboxyl terminal domains of the human HSP90 and differently affects these two domains. | Cisplatin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | In contrast, cisplatin induces a conformational change in HSP90N, but not HSP90C. | Cisplatin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | These results indicate that cisplatin modulates the HSP90 activities through two different mechanisms using the two distinct binding sites of the HSP90 molecule. | Cisplatin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | These results indicate that cisplatin modulates the HSP90 activities through two different mechanisms using the two distinct binding sites of the HSP90 molecule. | Cisplatin | heat shock protein 90 alpha family class A member 1 | Homo sapiens |