| 1 |
25668752 | Reaction design, discovery, and development as a foundation to function-oriented synthesis. | 2015 Mar 17 |
1 |
| 2 |
26405178 | A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. | 2015 Dec |
1 |
| 3 |
23511419 | Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. | 2013 Apr |
1 |
| 4 |
23564374 | Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors. | 2013 May |
1 |
| 5 |
23641970 | Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives. | 2013 Aug |
1 |
| 6 |
24280675 | Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies. | 2012 Jul 25 |
2 |
| 7 |
19850405 | Geldanamycin and its anti-cancer activities. | 2010 Apr 1 |
1 |
| 8 |
20828379 | 17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells. | 2010 Sep 9 |
2 |
| 9 |
20861078 | Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP. | 2010 Dec |
1 |
| 10 |
18393300 | Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation. | 2008 Dec |
1 |
| 11 |
18635747 | Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. | 2008 Oct |
2 |
| 12 |
18852129 | Cisplatin abrogates the geldanamycin-induced heat shock response. | 2008 Oct |
1 |
| 13 |
17252584 | Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete "sub-G1" peaks on DNA content histograms. | 2007 Mar |
2 |
| 14 |
16213582 | The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level. | 2006 May |
1 |
| 15 |
16432534 | Effects of geldanamycin on HIF-1alpha mediated angiogenesis and invasion in prostate cancer cells. | 2006 |
1 |
| 16 |
16546966 | Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. | 2006 Mar |
2 |
| 17 |
16938294 | Theileria-induced constitutive IKK activation is independent of functional Hsp90. | 2006 Sep 18 |
2 |
| 18 |
15757409 | Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update. | 2005 Feb |
1 |
| 19 |
16218955 | Inhibition of Hsp90 function delays and impairs recovery from heat shock. | 2005 Oct |
1 |
| 20 |
12571865 | Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts. | 2003 Feb |
1 |
| 21 |
12678776 | Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification. | 2003 May |
2 |
| 22 |
12811834 | Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. | 2003 Aug |
1 |
| 23 |
12881371 | The Hsp90 chaperone complex as a novel target for cancer therapy. | 2003 Aug |
1 |
| 24 |
11358819 | Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. | 2001 May 15 |
1 |
| 25 |
11406612 | Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. | 2001 Jun 1 |
1 |
| 26 |
10939589 | The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome. | 2000 Jul |
2 |
| 27 |
10632574 | Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells. | 1999 Oct |
2 |
| 28 |
10759403 | Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. | 1999 |
1 |
| 29 |
9428803 | Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway. | 1998 Feb |
1 |
| 30 |
9672245 | Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. | 1998 Jun |
1 |
| 31 |
9744771 | The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. | 1998 |
1 |
| 32 |
9201920 | Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus. | 1997 Jun 24 |
1 |
| 33 |
9367823 | Geldanamycin-induced destabilization of Raf-1 involves the proteasome. | 1997 Oct 29 |
1 |
| 34 |
7592678 | Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association. | 1995 Oct 13 |
1 |