Title : Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update.

Pub. Date : 2005 Feb

PMID : 15757409






1 Functional Relationships(s)
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1 Several chemically distinct Hsp90 inhibitors have shown encouraging antitumour activity in multiple preclinical model systems, and one Hsp90 inhibitor, the benzoquinone ansamycin 17-allylamino, 17-demethoxygeldanamycin, has completed five Phase I clinical trials, with a number of Phase II trials soon to be underway or in progress. benzoquinone ansamycin heat shock protein 90 alpha family class A member 1 Homo sapiens