Title : The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level.

Pub. Date : 2006 May

PMID : 16213582






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The benzoquinone ansamycin geldanamycin has been shown to bind to Hsp90 and to specifically inhibit this chaperone"s function, resulting in client protein destabilization. benzoquinone ansamycin heat shock protein 90 alpha family class A member 1 Homo sapiens