| 1 |
34979574 | Repercussion of cAMP and EPAC in Memory and Signaling. | 2022 Feb |
1 |
| 2 |
33872697 | Glucagon transiently stimulates mTORC1 by activation of an EPAC/Rap1 signaling axis. | 2021 Aug |
1 |
| 3 |
31996307 | Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration. | 2020 Apr 2 |
1 |
| 4 |
32041177 | RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology. | 2020 Feb 6 |
1 |
| 5 |
32120817 | Integration of Rap1 and Calcium Signaling. | 2020 Feb 27 |
1 |
| 6 |
33391941 | Inherited Platelet Function Disorder From Novel Mutations in RAS Guanyl-Releasing Protein-2 Confirmed by Sanger Sequencing. | 2020 Nov 25 |
1 |
| 7 |
29111327 | Overexpression of exchange protein directly activated by cAMP-1 (EPAC1) attenuates bladder cancer cell migration. | 2018 Jan 1 |
1 |
| 8 |
30353093 | The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases. | 2018 Oct 23 |
1 |
| 9 |
27649969 | Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias. | 2017 Jul 20 |
1 |
| 10 |
26061564 | Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion. | 2015 Jul |
1 |
| 11 |
24231725 | Cyclic AMP sensor EPAC proteins and energy homeostasis. | 2014 Feb |
1 |
| 12 |
23364803 | Role of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiology. | 2013 Apr 1 |
1 |
| 13 |
22738401 | Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes. | 2012 Aug 9 |
2 |
| 14 |
23139415 | Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. | 2012 Dec 28 |
1 |
| 15 |
19855995 | Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology. | 2010 Mar |
1 |
| 16 |
19210747 | EPAC proteins transduce diverse cellular actions of cAMP. | 2009 Sep |
1 |
| 17 |
19702438 | Pharmacological activation of guanine nucleotide exchange factors for the small GTPase Rap1 recruits high-affinity beta1 integrins as coreceptors for parvovirus B19: improved ex vivo gene transfer to human erythroid progenitor cells. | 2009 Dec |
1 |
| 18 |
18039662 | Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets. | 2008 Jan 25 |
1 |
| 19 |
18391018 | Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. | 2008 Jun |
1 |
| 20 |
18411261 | Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP. | 2008 Jul 11 |
1 |
| 21 |
17182900 | Rap1: a key regulator in cell-cell junction formation. | 2007 Jan 1 |
1 |
| 22 |
17300802 | Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach. | 2007 Apr 6 |
1 |
| 23 |
16316996 | The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane. | 2006 Feb 3 |
1 |
| 24 |
16507992 | Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. | 2006 Mar |
4 |
| 25 |
16757332 | Phospholipase Cepsilon guanine nucleotide exchange factor activity and activation of Rap1. | 2006 |
1 |
| 26 |
15525675 | Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. | 2005 Jan |
1 |
| 27 |
15632203 | Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. | 2005 Apr 15 |
1 |
| 28 |
15684418 | Superoxide anion radical modulates the activity of Ras and Ras-related GTPases by a radical-based mechanism similar to that of nitric oxide. | 2005 Apr 1 |
3 |
| 29 |
15313192 | Nitric oxide activates Rap1 and Ral in a Ras-independent manner. | 2004 Sep 10 |
2 |
| 30 |
15479739 | Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors. | 2004 Oct 11 |
2 |
| 31 |
12469113 | Structure and regulation of the cAMP-binding domains of Epac2. | 2003 Jan |
1 |
| 32 |
12578910 | Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. | 2003 Feb 17 |
1 |
| 33 |
14607972 | Rap1 GTPase: functions, regulation, and malignancy. | 2003 Oct |
4 |
| 34 |
11158328 | New signaling pathways for hormones and cyclic adenosine 3',5'-monophosphate action in endocrine cells. | 2001 Feb |
1 |
| 35 |
11503142 | Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons. | 2001 Sep 3 |
1 |
| 36 |
10835426 | CalDAG-GEFIII activation of Ras, R-ras, and Rap1. | 2000 Aug 18 |
1 |
| 37 |
10951566 | Cyclic AMP activates Ras. | 2000 Jul 27 |
1 |
| 38 |
10962559 | Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells. | 2000 Aug 17 |
1 |
| 39 |
10985780 | Mechanism of nucleotide release from Rho by the GDP dissociation stimulator protein. | 2000 Sep 19 |
1 |
| 40 |
10486569 | Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1. | 1999 Aug 20 |
1 |
| 41 |
9566869 | Activation of the small GTPase Ral in platelets. | 1998 May |
1 |
| 42 |
9843482 | All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. | 1998 Dec 1 |
1 |
| 43 |
9853756 | Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. | 1998 Dec 3 |
1 |
| 44 |
9856955 | A family of cAMP-binding proteins that directly activate Rap1. | 1998 Dec 18 |
1 |
| 45 |
9570294 | The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction. | 1997 |
1 |
| 46 |
9622053 | Role of Crk oncogene product in physiologic signaling. | 1997 |
1 |
| 47 |
8636102 | Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. | 1996 Mar 22 |
2 |
| 48 |
2110451 | Guanine nucleotide binding properties of rap1 purified from human neutrophils. | 1990 Apr 15 |
3 |