Title : Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor.

Pub. Date : 1996 Mar 22

PMID : 8636102






2 Functional Relationships(s)
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1 The interaction between Rap1A and RGF-RBD shows similar characteristics to the Ras-Raf interaction because it is blocked by mutations in the effector region (D38A) and it inhibits the dissociation of guanine nucleotide, which is the basis for the quantitative measurements in this work. Guanine Nucleotides RAP1A, member of RAS oncogene family Homo sapiens
2 As long as the cellular localizations of the different proteins and their biological functions are not clarified, these biochemical data seem to indicate that Ral-guanine nucleotide exchange factors is an effector molecule of Rap1A rather than of H-Ras. Guanine Nucleotides RAP1A, member of RAS oncogene family Homo sapiens