| 1 |
33040175 | Presence of the aldehyde dehydrogenase 2 variant ALDH2*2 considerably increases EC50 of nitroglycerin. | 2021 Mar |
2 |
| 2 |
32009064 | East Asians Variant Mitochondrial Aldehyde Dehydrogenase 2 Genotype Exacerbates Nitrate Tolerance in Patients With Coronary Spastic Angina. | 2020 Feb 25 |
7 |
| 3 |
32062637 | Nitroglycerin Tolerance in Patients With ALDH2 Variant. | 2020 Feb 25 |
1 |
| 4 |
31162244 | Role of Mitochondrial Aldehyde Dehydrogenase in Nitroglycerin-Mediated Vasodilation: Observations Concerning the Dose-Response Relationship. | 2019 Jun |
2 |
| 5 |
31250045 | Influence of the aldehyde dehydrogenase 2 polymorphism on the vasodilatory effect of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension. | 2019 Oct |
7 |
| 6 |
29358221 | Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance. | 2018 Apr |
8 |
| 7 |
29431026 | The potential of aldehyde dehydrogenase 2 as a therapeutic target in cardiovascular disease. | 2018 Mar |
2 |
| 8 |
28342890 | Vasodilatory effect of nitroglycerin in Japanese subjects with different aldehyde dehydrogenase 2 (ALDH2) genotypes. | 2017 Oct 1 |
2 |
| 9 |
26832618 | [Fundamental Properties of Aldehyde Dehydrogenase 2 (ALDH2) and the Importance of the ALDH2 Polymorphism]. | 2016 |
1 |
| 10 |
27323160 | Aldehyde dehydrogenase 2 protects human umbilical vein endothelial cells against oxidative damage and increases endothelial nitric oxide production to reverse nitroglycerin tolerance. | 2016 Jun 10 |
7 |
| 11 |
27679490 | Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin. | 2016 Nov 11 |
10 |
| 12 |
25576686 | Aldehyde dehydrogenase-independent bioactivation of nitroglycerin in porcine and bovine blood vessels. | 2015 Feb 15 |
4 |
| 13 |
25591559 | Effect of aldehyde dehydrogenase 2 gene polymorphism on hemodynamics after nitroglycerin intervention in Northern Chinese Han population. | 2015 Jan 20 |
6 |
| 14 |
25754766 | Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans. | 2015 Jul |
2 |
| 15 |
25098345 | Involvement of anandamide transporter in calcitonin gene-related peptide expression stimulated by nitroglycerin and influence of ALDH2 Glu504Lys polymorphism. | 2014 Nov |
2 |
| 16 |
25174989 | The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance. | 2014 Nov |
7 |
| 17 |
22994391 | Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation. | 2013 Feb |
7 |
| 18 |
22040938 | Nitroglycerin use in myocardial infarction patients. | 2012 |
6 |
| 19 |
22909898 | Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP). | 2012 Oct |
4 |
| 20 |
22988236 | Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. | 2012 Nov 2 |
10 |
| 21 |
21252222 | Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro. | 2011 Mar 18 |
1 |
| 22 |
21536753 | Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation. | 2011 Aug |
6 |
| 23 |
21818694 | Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites. | 2011 Dec |
3 |
| 24 |
22021773 | Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial. | 2011 Jul 18 |
4 |
| 25 |
22049071 | ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. | 2011 Nov 2 |
8 |
| 26 |
19906643 | Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1. | 2010 Jan 8 |
10 |
| 27 |
20072908 | Nitrate reductase activity of mitochondrial aldehyde dehydrogenase (ALDH-2) as a redox sensor for cardiovascular oxidative stress. | 2010 |
1 |
| 28 |
21081219 | Organic nitrates and nitrate tolerance--state of the art and future developments. | 2010 |
1 |
| 29 |
18834868 | Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment. | 2009 Mar 16 |
7 |
| 30 |
18951990 | Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: lack of evidence for a role in the bioactivation of nitroglycerin. | 2009 Feb |
2 |
| 31 |
19307691 | Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress. | 2009 Jan-Feb |
1 |
| 32 |
19346443 | Monitoring white blood cell mitochondrial aldehyde dehydrogenase activity: implications for nitrate therapy in humans. | 2009 Jul |
4 |
| 33 |
19506075 | Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2. | 2009 Jul 24 |
10 |
| 34 |
19533580 | Demethylbellidifolin prevents nitroglycerin tolerance via improved aldehyde dehydrogenase 2 activity. | 2009 Nov |
2 |
| 35 |
19911129 | Efficient expression of codon-adapted human acetaldehyde dehydrogenase 2 cDNA with 6xHis tag in Pichia pastoris. | 2009 Oct |
1 |
| 36 |
20005475 | Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? | 2009 Jul |
1 |
| 37 |
18272654 | Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. | 2008 Jul |
4 |
| 38 |
18289604 | Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2. | 2008 Mar 26 |
3 |
| 39 |
18450747 | Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases. | 2008 Jun 27 |
11 |
| 40 |
18574453 | The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles. | 2008 Sep |
3 |
| 41 |
18772068 | Evidence for involvement of calcitonin gene-related peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism. | 2008 Sep 9 |
9 |
| 42 |
18786921 | Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin. | 2008 Nov 7 |
7 |
| 43 |
18946854 | [Recent findings on nitrates: their action, bioactivation and development of tolerance]. | 2008 Oct |
4 |
| 44 |
17327228 | Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. | 2007 Apr 27 |
2 |
| 45 |
17585900 | Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. | 2007 Sep 24 |
4 |
| 46 |
17967228 | [The relationship between aldehyde dehydrogenase-2 gene polymorphisms and efficacy of nitroglycerin]. | 2007 Aug |
10 |
| 47 |
18061070 | Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels. | 2007 Dec 4 |
6 |
| 48 |
16440063 | Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. | 2006 Feb |
4 |
| 49 |
17053193 | Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants. | 2006 Nov 10 |
1 |
| 50 |
15377279 | Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide. | 2005 Feb 1 |
1 |