Title : Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP).

Pub. Date : 2012 Oct

PMID : 22909898






4 Functional Relationships(s)
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Protein Name
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1 Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP). Nitroglycerin aldehyde dehydrogenase 2 family member Homo sapiens
2 At the end of GTN infusion, ALDH2*1/*1 homozygous patients showed higher degrees of both the absolute decrease in SBP (DSBP) (p < 0.001) and increase in LVEF (p < 0.001) than carriers of the ALDH2*2 allele. Nitroglycerin aldehyde dehydrogenase 2 family member Homo sapiens
3 At the end of GTN infusion, ALDH2*1/*1 homozygous patients showed higher degrees of both the absolute decrease in SBP (DSBP) (p < 0.001) and increase in LVEF (p < 0.001) than carriers of the ALDH2*2 allele. Nitroglycerin aldehyde dehydrogenase 2 family member Homo sapiens
4 CONCLUSIONS: ALDH2*2 polymorphism is associated with contributions of CGRP to GTN response in CHF patients. Nitroglycerin aldehyde dehydrogenase 2 family member Homo sapiens