Pub. Date : 2013 Feb
PMID : 22994391
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 2 | BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 3 | BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 4 | BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 5 | BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 6 | In PK1(ALDH2), GTN biotransformation was significantly increased as a result of increased glyceryl-1,2-dinitrate formation compared to wild-type or PK1(vector). | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 7 | However, the incubation of PK1(ALDH2) with 1 or 10 muM GTN did not alter GTN-induced cGMP accumulation compared with wild-type or PK1(vector) cells. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |