Pub. Date : 2009 Jul
PMID : 19346443
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast to PETN, acute GTN treatment resulted in a 60% decrease in WBC ALDH-2 activity (high-performance liquid chromatography), 30% reduction of nitrate bioactivation, and 25% decrease in serum antioxidant capacity (fluorescence assay), which all were prevented by pretreatment with LA. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 2 | Treatment with GTN, but not PETN, acutely inhibits ALDH-2 activity and nitrate bioactivation in healthy volunteers. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 3 | Assessment of WBC ALDH-2 activity could be used as an easily accessible marker for the detection of nitroglycerin-induced tachyphylaxis in humans and may be of high clinical interest because recent data suggest that ALDH-2 activity correlates with protection from ischemic heart damage in infarct models. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |
| 4 | Assessment of WBC ALDH-2 activity could be used as an easily accessible marker for the detection of nitroglycerin-induced tachyphylaxis in humans and may be of high clinical interest because recent data suggest that ALDH-2 activity correlates with protection from ischemic heart damage in infarct models. | Nitroglycerin | aldehyde dehydrogenase 2 family member | Homo sapiens |