| 1 |
34776512 | Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer's disease. | 2022 Feb |
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33848635 | Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice. | 2021 Jul |
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33881611 | Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain. | 2021 Jun |
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34769222 | Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice. | 2021 Oct 30 |
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| 5 |
30391539 | Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2. | 2019 Apr |
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29673150 | Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation. | 2018 Apr 17 |
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26697885 | Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons. | 2016 Mar 18 |
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25547635 | Neuron Loss and Behavioral Deficits in the TBA42 Mouse Model Expressing N-Truncated Pyroglutamate Amyloid-β3-42. | 2015 |
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| 9 |
25666182 | Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease. | 2015 Apr |
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| 10 |
26453001 | An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice. | 2015 Dec |
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| 11 |
24158021 | Pyroglutamate-modified amyloid-β protein demonstrates similar properties in an Alzheimer's disease familial mutant knock-in mouse and Alzheimer's disease brain. | 2014 |
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| 12 |
24595198 | Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. | 2014 |
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| 13 |
22064070 | Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody. | 2012 |
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| 14 |
22267726 | Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease. | 2012 Mar 9 |
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| 15 |
21301857 | Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms. | 2011 Jun |
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| 16 |
21795681 | Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid. | 2011 Sep 30 |
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| 17 |
21900558 | Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. | 2011 Sep 7 |
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| 18 |
19823761 | Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. | 2010 Jan |
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| 19 |
19545911 | Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits. | 2009 Aug 18 |
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| 20 |
18836460 | Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. | 2008 Oct |
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