| 1 |
33436626 | Structural insights into TSC complex assembly and GAP activity on Rheb. | 2021 Jan 12 |
1 |
| 2 |
34801548 | Development of a versatile HPLC-based method to evaluate the activation status of small GTPases. | 2021 Dec |
6 |
| 3 |
30266989 | CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia. | 2019 Feb |
1 |
| 4 |
30514904 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. | 2019 Feb |
1 |
| 5 |
30647914 | Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates. | 2019 |
1 |
| 6 |
29320991 | An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation. | 2018 Jan 10 |
1 |
| 7 |
27399332 | Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth. | 2017 Feb 9 |
1 |
| 8 |
28212107 | Rheb in neuronal degeneration, regeneration, and connectivity. | 2017 May 1 |
1 |
| 9 |
28625796 | The characterization of RHEB gene and its responses to hypoxia and thermal stresses in the small abalone Haliotis diversicolor. | 2017 Aug |
2 |
| 10 |
29750207 | Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A. | 2017 Oct 31 |
6 |
| 11 |
26781224 | Rag GTPase in amino acid signaling. | 2016 Apr |
1 |
| 12 |
25422319 | Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity. | 2015 Jan 9 |
2 |
| 13 |
24235024 | The importance of autophagy in cardioprotection. | 2014 Mar |
1 |
| 14 |
24316235 | RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. | 2014 Mar |
1 |
| 15 |
24337580 | Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. | 2014 Jan 31 |
1 |
| 16 |
24368770 | Rheb GTPase regulates β-secretase levels and amyloid β generation. | 2014 Feb 28 |
1 |
| 17 |
24648513 | Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). | 2014 May 2 |
2 |
| 18 |
24863881 | Recent progress in the study of the Rheb family GTPases. | 2014 Sep |
1 |
| 19 |
25402640 | Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids. | 2014 Nov 13 |
1 |
| 20 |
23178303 | Deacetylated αβ-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading. | 2013 Feb |
6 |
| 21 |
23863162 | Rheb and Rags come together at the lysosome to activate mTORC1. | 2013 Aug |
1 |
| 22 |
22356909 | Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908. | 2012 Apr 6 |
1 |
| 23 |
22819219 | An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis. | 2012 Sep 5 |
4 |
| 24 |
22987636 | Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells. | 2012 Sep 15 |
2 |
| 25 |
21474067 | Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. | 2011 Apr 8 |
1 |
| 26 |
21734039 | Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation. | 2011 Sep |
1 |
| 27 |
21784859 | Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. | 2011 Sep 16 |
1 |
| 28 |
22102801 | Computational modeling and analysis of insulin induced eukaryotic translation initiation. | 2011 Nov |
1 |
| 29 |
20018863 | Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics. | 2010 Feb 19 |
2 |
| 30 |
20048149 | Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL. | 2010 Mar 19 |
1 |
| 31 |
20177060 | Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia. | 2010 Apr 16 |
1 |
| 32 |
18765678 | Amino acid regulation of TOR complex 1. | 2009 Apr |
6 |
| 33 |
19000755 | Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. | 2009 Feb |
1 |
| 34 |
19143636 | Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. | 2009 Feb |
1 |
| 35 |
19176517 | Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR. | 2009 Jan 27 |
1 |
| 36 |
19222999 | Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway. | 2009 Mar 18 |
1 |
| 37 |
19346248 | Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. | 2009 May 29 |
1 |
| 38 |
19570981 | Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein. | 2009 Aug 28 |
2 |
| 39 |
18550814 | Phospholipase D1 is an effector of Rheb in the mTOR pathway. | 2008 Jun 17 |
2 |
| 40 |
18676370 | Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. | 2008 Nov 7 |
2 |
| 41 |
17360675 | Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. | 2007 Feb 27 |
1 |
| 42 |
17928295 | Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. | 2007 Dec 7 |
2 |
| 43 |
17991864 | Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. | 2007 Nov 9 |
2 |
| 44 |
16170341 | Regulation of the small GTPase Rheb by amino acids. | 2006 Feb 2 |
2 |
| 45 |
16707451 | Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway. | 2006 May 15 |
1 |
| 46 |
16728407 | Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase. | 2006 Jul 21 |
1 |
| 47 |
16916489 | Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies. | 2006 Jul |
1 |
| 48 |
15728574 | Structural basis for the unique biological function of small GTPase RHEB. | 2005 Apr 29 |
7 |
| 49 |
15772076 | The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. | 2005 May 13 |
3 |
| 50 |
15775987 | Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. | 2005 Mar 23 |
1 |