Title : The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Pub. Date : 2005 May 13

PMID : 15772076






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TSC2 contains a GTPase-activator domain that promotes hydrolysis of GTP bound to Rheb, which positively regulates mTOR signaling. Guanosine Triphosphate Ras homolog, mTORC1 binding Homo sapiens
2 Although TSC2 is not required for amino acid control of mTOR, amino acid withdrawal does decrease the proportion of Rheb in the active GTP-bound state. Guanosine Triphosphate Ras homolog, mTORC1 binding Homo sapiens
3 Mutants of Rheb that cannot bind GTP or GDP can interact with mTOR complexes. Guanosine Triphosphate Ras homolog, mTORC1 binding Homo sapiens