Title : CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia.

Pub. Date : 2019 Feb

PMID : 30266989






1 Functional Relationships(s)
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1 Specifically, CBAP facilitated Akt-dependent TSC2 phosphorylation in cell-based assays and in vitro analysis, decreased lysosomal localization of TSC2, and elevated Rheb-GTP loading and subsequent activation of mTORC1 signaling. Guanosine Triphosphate Ras homolog, mTORC1 binding Homo sapiens