Bortezomib

nuclear factor kappa B subunit 1 ; Homo sapiens







166 Article(s)
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1 35604822 A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-κB Activation and Drug Resistance. 2022 May 23 2
2 32381576 Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers. 2021 Apr 1 1
3 33289516 Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization. 2021 Jan 15 4
4 33406639 Activation of Serum/Glucocorticoid Regulated Kinase 1/Nuclear Factor-κB Pathway Are Correlated with Low Sensitivity to Bortezomib and Ixazomib in Resistant Multiple Myeloma Cells. 2021 Jan 4 4
5 33572814 HDAC6-Selective Inhibitor Overcomes Bortezomib Resistance in Multiple Myeloma. 2021 Jan 29 1
6 33674562 Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling. 2021 Mar 5 3
7 33787860 Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection. 2021 Apr 13 1
8 33973606 The TiO2-μ implant residual is more toxic than the Al2O3-n implant residual via blocking LAP and inducing macrophage polarization. 2021 May 20 1
9 34390764 Albendazole inhibits NF-κB signaling pathway to overcome tumor stemness and bortezomib resistance in multiple myeloma. 2021 Nov 1 1
10 34501388 Bone Marrow Microenvironment Interplay and Current Clinical Practice in Multiple Myeloma: A Review of the Balkan Myeloma Study Group. 2021 Aug 31 2
11 34571936 Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation. 2021 Sep 2 1
12 32142770 Anti-leukemic effects of histone deacetylase (HDAC) inhibition in acute lymphoblastic leukemia (ALL) cells: Shedding light on mitigating effects of NF-κB and autophagy on panobinostat cytotoxicity. 2020 May 15 2
13 32160736 PI3K Abrogation Using Pan-PI3K Inhibitor BKM120 Gives Rise to a Significant Anticancer Effect on AML-Derived KG-1 Cells by Inducing Apoptosis and G2/M Arrest 2020 Aug 28 2
14 32683901 Proteasomal Inhibition Potentiates Latent HIV Reactivation. 2020 Oct 1
15 33187351 Supramolecular Caffeic Acid and Bortezomib Nanomedicine: Prodrug Inducing Reactive Oxygen Species and Inhibiting Cancer Cell Survival. 2020 Nov 11 1
16 33191863 Blockade of PLD1 potentiates the antitumor effects of bortezomib in multiple myeloma cells by inhibiting the mTOR/NF-κB signal pathway. 2020 Dec 2
17 33214335 CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma. 2020 Aug 1
18 33330064 Study on Tim3 Regulation of Multiple Myeloma Cell Proliferation via NF-κB Signal Pathways. 2020 2
19 31347196 Platycodin D inhibits proliferation, migration and induces chemosensitization through inactivation of the NF-κB and JAK2/STAT3 pathways in multiple myeloma cells. 2019 Dec 1
20 31631595 [Bortezomib Inhibits Extranodal Natural Killer/T Cell Lymphoma, Nasal Type by Targeting NF-κB Signaling Pathway]. 2019 May 3
21 29279332 Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-κB activity and increases drug resistance in multiple myeloma. 2018 Feb 16 5
22 29441489 Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway. 2018 Sep 4
23 29468963 NF-κB-IKKβ Pathway as a Target for Drug Development: Realities, Challenges and Perspectives. 2018 1
24 29695239 Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity. 2018 Apr 25 1
25 29699990 TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia. 2018 Jun 21 1
26 30487672 Ameliorating effects of bortezomib, a proteasome inhibitor, on development of dextran sulfate sodium-induced murine colitis. 2018 Nov 1
27 33445276 Bortezomib Increases the Cancer Therapeutic Efficacy of Poly(amino acid)-Doxorubicin. 2018 Jun 11 2
28 27923823 Bortezomib Relieves Immune Tolerance in Nasopharyngeal Carcinoma via STAT1 Suppression and Indoleamine 2,3-Dioxygenase Downregulation. 2017 Jan 1
29 28339079 A p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of EBV-related B cell origin cancer cells via regulation of NF-κB. 2017 May 3
30 29386876 Bortezomib inhibits proliferation, migration, and TGF-β1-induced epithelial-mesenchymal transition of RPE cells. 2017 2
31 26227222 Synergistic action of 5Z-7-oxozeaenol and bortezomib in inducing apoptosis of Burkitt lymphoma cell line Daudi. 2016 Jan 1
32 26683226 MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment. 2016 Jan 26 1
33 27016342 Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype. 2016 Sep 2
34 27300524 A phase II trial evaluating the effects and intra-tumoral penetration of bortezomib in patients with recurrent malignant gliomas. 2016 Aug 2
35 27806331 XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma. 2016 Nov 29 2
36 25363231 NFKB1 -94ins/delATTG polymorphism is a novel prognostic marker in first line-treated multiple myeloma. 2015 Mar 1
37 25613668 TM-233, a novel analog of 1'-acetoxychavicol acetate, induces cell death in myeloma cells by inhibiting both JAK/STAT and proteasome activities. 2015 Apr 2
38 25661379 Blocking NF-κB sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species. 2015 Feb 5
39 25686825 NF-κB signaling mediates acquired resistance after PARP inhibition. 2015 Feb 28 1
40 25766331 NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways. 2015 Mar 12 7
41 25823927 Aberrant nuclear factor-kappa B activity in acute myeloid leukemia: from molecular pathogenesis to therapeutic target. 2015 Mar 20 3
42 25895124 Anti-β₂-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy. 2015 Apr 20 1
43 26099967 The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells. 2015 Aug 2
44 26431276 Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-κB crosstalk. 2015 Oct 20 4
45 26494122 Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity. 2015 Dec 15 1
46 27358886 Current approaches and advance in mantle cell lymphoma treatment. 2015 1
47 23697845 Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma. 2014 Feb 5
48 24262132 Post-transplant cyclophosphamide and bortezomib inhibit dendritic cell maturation and function and alter their IκB and NFκB. 2014 Jan 1
49 24286313 Establishment and characterization of bortezomib-resistant U266 cell line: constitutive activation of NF-κB-mediated cell signals and/or alterations of ubiquitylation-related genes reduce bortezomib-induced apoptosis. 2014 May 2
50 24481412 IKKβ inhibitor in combination with bortezomib induces cytotoxicity in breast cancer cells. 2014 Apr 7