Title : Anti-leukemic effects of histone deacetylase (HDAC) inhibition in acute lymphoblastic leukemia (ALL) cells: Shedding light on mitigating effects of NF-κB and autophagy on panobinostat cytotoxicity.

Pub. Date : 2020 May 15

PMID : 32142770






2 Functional Relationships(s)
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1 Accordingly, we found that the inhibition of NF-kappaB pathway using bortezomib boosted the effect of panobinostat, indicating that panobinostat-induced apoptosis could be attenuated through the activation of the NF-kappaB pathway. Bortezomib nuclear factor kappa B subunit 1 Homo sapiens
2 Accordingly, we found that the inhibition of NF-kappaB pathway using bortezomib boosted the effect of panobinostat, indicating that panobinostat-induced apoptosis could be attenuated through the activation of the NF-kappaB pathway. Bortezomib nuclear factor kappa B subunit 1 Homo sapiens