Pub. Date : 2014 Feb
PMID : 23697845
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, a panel of ABC cell lines was used to examine the effect of bortezomib, a proteasome inhibitor which blocks degradation of IkappaBalpha and consequently inhibits NFkappaB activity. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We next determined the status of the NFkappaB pathway following bortezomib treatment and found that there was accumulation of IkappaBalpha without affecting its phosphorylation status at an early time point. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Electrophoretic mobility shift assay showed that bortezomib treatment inhibited constitutive nuclear NFkappaB in ABC cell lines. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Furthermore, treatment of ABC cell lines with bortezomib for 48 h also down-regulated the expression of NFkappaB-regulated gene products, such as IkappaBalpha, Bcl-2, Bcl-Xl, XIAP and survivin, leading to apoptosis via the mitochondrial apoptotic pathway. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Altogether, these results suggest that NFkappaB may be a potential target for therapeutic intervention in DLBCL using proteasomal inhibitors such as bortezomib. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |