nilotinib

ABL proto-oncogene 1, non-receptor tyrosine kinase ; Homo sapiens







274 Article(s)
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251 17538248 Imatinib and nilotinib induce apoptosis of chronic myeloid leukemia cells through a Bim-dependant pathway modulated by cytokines. 2007 Jun 2
252 17613767 The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines. 2007 Jul 2
253 17642017 Drug evaluation: Nilotinib - a novel Bcr-Abl tyrosine kinase inhibitor for the treatment of chronic myelocytic leukemia and beyond. 2007 Jul 2
254 17701954 Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. 2007 Sep 15 1
255 17715389 Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. 2007 Nov 15 6
256 17720881 Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. 2007 Dec 1 2
257 17785585 Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. 2007 Dec 1 1
258 17853901 Flying under the radar: the new wave of BCR-ABL inhibitors. 2007 Oct 2
259 17964980 [Treatment of chronic myeloid leukemia in 2007]. 2007 Oct 1
260 17964981 [Acute lymphoblastic leukemia with Philadelphia chromosome: treatment with kinase inhibitors]. 2007 Oct 1
261 17987222 Nilotinib therapy in chronic myelogenous leukemia. 2007 Oct 1
262 18067005 Strategies for overcoming imatinib resistance in chronic myeloid leukemia. 2007 Dec 1
263 19707322 Nilotinib: a novel encouraging therapeutic option for chronic myeloid leukemia patients with imatinib resistance or intolerance. 2007 Jun 1
264 16537804 Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells. 2006 Jul 15 2
265 16597591 OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. 2006 Jul 15 1
266 16614241 Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107). 2006 Aug 15 3
267 16721371 AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL. 2006 Jun 19 4
268 16772610 Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. 2006 Oct 1 4
269 17106016 Novel treatment strategies for chronic myeloid leukemia. 2006 Dec 1 1
270 17124064 Defining and managing imatinib resistance. 2006 1
271 18221045 Second generation Abl kinase inhibitors and novel compounds to eliminate the Bcr-Abl/T315I clone. 2006 Nov 1
272 15930265 In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. 2005 Jun 1 2
273 16000593 AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia. 2005 Jul 1 3
274 16078266 AMN107, a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute lymphoblastic leukemia cells. 2005 Sep 15 1