Pub. Date : 2005 Jul 1
PMID : 16000593
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia. | nilotinib | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | AMN107 is a novel, orally bioavailable ATP-competitive inhibitor of Bcr-Abl. | nilotinib | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | AMN107 inhibited autophosphorylation of Bcr-Abl kinase more effectively than imatinib in all cell lines. | nilotinib | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |