Title : OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib.

Pub. Date : 2006 Jul 15

PMID : 16597591






1 Functional Relationships(s)
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1 IC50 values for the more potent BCR-ABL inhibitor nilotinib (AMN107) did not correlate with IC50(imatinib) (R(2) =-0.0561, P > .05). nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens