Pub. Date : 2010 Jun 15
PMID : 19739070
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By using hMLH1 expressing clones or cells transduced with the hMLH1-expressing adenovirus as well as siRNA technology, we show that in response to SN-38-induced DNA damage the MMR proficient (MMR(+)) cells make: (i) a stronger G2/M arrest, (ii) a subsequent longer tetraploid G1 arrest, (iii) a stronger activation of Chk1 and Chk2 kinases than the MMR deficient (MMR(-)) counterparts. | Irinotecan | checkpoint kinase 1 | Homo sapiens |