Title : Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.

Pub. Date : 2012 Apr

PMID : 22446188






1 Functional Relationships(s)
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1 We therefore tested whether inhibition of Chk1 could potentiate the cytotoxicity of the DNA damaging agent irinotecan in TNBC using xenotransplant tumor models. Irinotecan checkpoint kinase 1 Homo sapiens