Pub. Date : 2002 Nov
PMID : 12370755
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38. | Irinotecan | checkpoint kinase 1 | Homo sapiens |
| 2 | Increased chk1 phosphorylation at Ser345 induced by SN-38 was accompanied by the observed G2 phase arrest in the A253 cell line, while significant downregulation of chk1 and cdc25C phosphorylation, which resulted in the abrogation of G2/M checkpoint arrest, was noted in FaDu cells at this timepoint. | Irinotecan | checkpoint kinase 1 | Homo sapiens |
| 3 | These results suggest that alterations of chk1 signaling are associated with the response to topoisomerase I poison SN-38. | Irinotecan | checkpoint kinase 1 | Homo sapiens |