Bortezomib

interleukin 6 ; Homo sapiens







32 Article(s)
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1 34558232 A 3D-Bioprinted Multiple Myeloma Model. 2022 Apr 2
2 34648407 Clinical significance of SIRT3 and inflammatory factors in multiple myeloma patients with bortezomib-induced peripheral neuropathy: a cohort study. 2021 Dec 1
3 31337650 IL6 Promotes a STAT3-PRL3 Feedforward Loop via SHP2 Repression in Multiple Myeloma. 2019 Sep 15 1
4 29693175 Microvesicles shed from bortezomib-treated or lenalidomide-treated human myeloma cells inhibit angiogenesis in vitro. 2018 Jun 2
5 30292410 Enhanced antitumor effect of combination of annexin A1 knockdown and bortezomib treatment in multiple myeloma in vitro and in vivo. 2018 Nov 2 1
6 30455994 Biologic Agents in the Treatment of Multicentric Castleman Disease. 2018 Oct 1
7 25655379 Phase 1 study in Japan of siltuximab, an anti-IL-6 monoclonal antibody, in relapsed/refractory multiple myeloma. 2015 Mar 1
8 25791477 Anticancer drug bortezomib increases interleukin-8 expression in human monocytes. 2015 May 1 1
9 24619424 The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes. 2014 May 2 1
10 24713927 MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells. 2014 May 22 1
11 24908316 Quantitative analysis of bortezomib-induced IL-8 gene expression in ovarian cancer cells. 2014 1
12 25064746 Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels. 2014 Dec 2
13 23063726 Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-κB activity. 2013 Feb 1
14 21214673 Inhibition of tumor growth and sensitization to chemotherapy by RNA interference targeting interleukin-6 in the androgen-independent human prostate cancer PC3 model. 2011 Apr 2
15 20201942 Emergent T-helper 2 profile with high interleukin-6 levels correlates with the appearance of bortezomib-induced neuropathic pain. 2010 Jun 1
16 20663948 Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma. 2010 Nov 1
17 19327235 The proteasome inhibitor bortezomib inhibits the release of NFkappaB-inducible cytokines and induces apoptosis of activated T cells from rheumatoid arthritis patients. 2009 Jan-Feb 1
18 18316628 Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia. 2008 May 1 1
19 18690088 Blockage of interleukin-6 signaling with 6-amino-4-quinazoline synergistically induces the inhibitory effect of bortezomib in human U266 cells. 2008 Sep 2
20 18989635 Stromal cells in bone marrow play important roles in pro-inflammatory cytokine secretion causing fever following bortezomib administration in patients with multiple myeloma. 2008 Nov 1
21 19383353 Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells. 2008 Dec 1
22 16820206 Bortezomib is an effective agent for MDS/MPD syndrome with 5q- anomaly and thrombocytosis. 2007 Apr 2
23 17975159 Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma. 2007 Nov 1 7
24 16397231 Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells. 2006 Jan 1 3
25 16584593 [Effects of proteasome inhibitor PS-341 on the multiple cytokine expressions of mesenchymal stem cells from bone marrow in patients with multiple myeloma]. 2006 Feb 2
26 16986718 [Bortezomib-induced tumor lysis syndrome with a remarkable elevation of LDH in a case of relapsed and therapy-resistant multiple myeloma]. 2006 Aug 1
27 15090453 Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants. 2004 Aug 1 2
28 15217830 Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells. 2004 Oct 15 1
29 15561686 Multiple myeloma. 2004 2
30 14627979 Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. 2003 Nov 20 5
31 11306489 The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. 2001 Apr 1 2
32 11740818 Novel therapies targeting the myeloma cell and its bone marrow microenvironment. 2001 Dec 3