Pub. Date : 2001 Dec
PMID : 11740818
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PS-341 inhibits p44/42 mitogen-activated protein kinase (MAPK) growth signaling triggered by IL-6 and induces apoptosis, despite induction of p21 and p27, in p53 wild-type and p53 mutant MM cells. | Bortezomib | interleukin 6 | Homo sapiens |
| 2 | PS-341 adds to the anti-MM activity of dexamethasone and overcomes IL-6-mediated protection against dexamethasone-induced apoptosis. | Bortezomib | interleukin 6 | Homo sapiens |
| 3 | PS-341 blocks the paracrine growth of human MM cells by decreasing their adherence to BMSCs and related NF-kappaB-dependent induction of IL-6 secretion in BMSCs. | Bortezomib | interleukin 6 | Homo sapiens |