Title : Bortezomib is an effective agent for MDS/MPD syndrome with 5q- anomaly and thrombocytosis.

Pub. Date : 2007 Apr

PMID : 16820206






2 Functional Relationships(s)
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1 We present here the first case in the literature with MDS/MPD syndrome, sole 5q- anomaly and thrombocytosis in which bortezomib administration normalized platelet count, produced a major erythroid response, and reduced levels of interleukin-6 (IL-6) and TNF-alpha while increased levels of IL-4 in the bone marrow plasma. Bortezomib interleukin 6 Homo sapiens
2 We present here the first case in the literature with MDS/MPD syndrome, sole 5q- anomaly and thrombocytosis in which bortezomib administration normalized platelet count, produced a major erythroid response, and reduced levels of interleukin-6 (IL-6) and TNF-alpha while increased levels of IL-4 in the bone marrow plasma. Bortezomib interleukin 6 Homo sapiens