Title : Metformin inhibits mTOR-HIF-1α axis and profibrogenic and inflammatory biomarkers in thioacetamide-induced hepatic tissue alterations.

Pub. Date : 2019 Jun

PMID : 30334569






2 Functional Relationships(s)
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1 Metformin also significantly ( p < 0.05) inhibited TAA-induced HIF-1alpha, mTOR, the profibrogenic biomarker alpha-smooth muscle actin, tissue inhibitor of metalloproteinases-1, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase in harvested liver homogenates and blood samples. Metformin interleukin 6 Homo sapiens
2 Metformin also significantly ( p < 0.05) inhibited TAA-induced HIF-1alpha, mTOR, the profibrogenic biomarker alpha-smooth muscle actin, tissue inhibitor of metalloproteinases-1, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase in harvested liver homogenates and blood samples. Metformin interleukin 6 Homo sapiens