Title : Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer.

Pub. Date : 2018 Jun

PMID : 29545331






2 Functional Relationships(s)
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1 For the first time, we found that the tumor stroma of patients with routine metformin administration exhibited lower IL6 expression. Metformin interleukin 6 Homo sapiens
2 Mechanistically, we found that metformin inhibited IL6 secretion via suppressing NFkappaB signaling, an upstream controller of stromal inflammation. Metformin interleukin 6 Homo sapiens