Indomethacin

nitric oxide synthase 2 ; Rattus norvegicus







56 Article(s)
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1 33161252 Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors. 2020 Dec 1
2 28474155 N-(2-Hydroxyphenyl)acetamide: a Novel Suppressor of RANK/RANKL Pathway in Collagen-Induced Arthritis Model in Rats. 2017 Aug 1
3 28566633 Co-administration of Magnesium Ion Prevents Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rats. 2017 3
4 29064425 Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy. 2017 Oct 24 2
5 26439477 Protective activity of crocin against indomethacin-induced gastric lesions in rats. 2016 Jan 1
6 27397599 Influence of Adrenalectomy on Protective Effects of Urocortin I, a Corticotropin-Releasing Factor, Against Indomethacin-Induced Enteropathy in Rats. 2016 1
7 24713141 Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors. 2014 Jun 2
8 23201077 Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage. 2013 Jan 10 1
9 21305324 Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing. 2011 May 2
10 19707872 Urocortin prevents indomethacin-induced small intestinal lesions in rats through activation of CRF2 receptors. 2010 Jun 2
11 19802525 TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. 2010 Mar 1
12 20136840 Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat. 2010 Apr 1
13 20610858 Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1. 2010 Jun 4
14 22545970 Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats. 2010 Nov 2
15 19101800 Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism. 2009 Nov 3
16 19122291 Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat. 2009 Jan 3
17 20065509 Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats. 2009 Dec 1
18 17503181 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats. 2008 Jan 4
19 18209962 Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration. 2008 Jan 2
20 18216606 Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase. 2008 Feb 1
21 18306037 Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. 2008 Oct 3
22 17202747 Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression. 2007 Jan 1
23 17284196 Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats. 2007 Jan 1
24 16838118 Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production. 2006 Aug 1
25 16920514 The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid. 2006 Sep 2
26 16944022 Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs. 2006 Jul 2
27 15610444 Functional mechanism underlying cyclooxygenase-2 expression in rat small intestine following administration of indomethacin: relation to intestinal hypermotility. 2005 Jan 3
28 16133968 Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression. 2005 Sep 2
29 14988416 In vivo study on cross talk between inducible nitric-oxide synthase and cyclooxygenase in rat gastric mucosa: effect of cyclooxygenase activity on nitric oxide production. 2004 Jun 1
30 15067210 Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus. 2004 1
31 15167974 The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats. 2004 Jun 1
32 12568917 Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat. 2003 Feb 7 3
33 11855677 Protective effect of thiaton, an antispasmodic drug, against indomethacin-induced intestinal damage in rats. 2002 Jan 2
34 11991626 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors. 2002 Apr 1
35 12379813 Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats. 2002 2
36 12438549 Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events. 2002 Dec 2
37 11292602 Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS. 2001 May 1
38 11427040 Involvement of inducible isoforms of COX and NOS in streptozotocin-pancreatic damage in the rat: interactions between nitridergic and prostanoid pathway. 2001 Jun 1
39 11493346 Apoptosis of rat gastric mucosa and of primary cultures of gastric epithelial cells by indomethacin: role of inducible nitric oxide synthase and interleukin-8. 2001 Aug 1
40 11686837 Protective effect of rebamipide on indomethacin-induced intestinal damage in rats. 2001 Oct 1
41 11698048 Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs. 2001 Oct 19 2
42 11713966 Nitric oxide inhibitors ameliorate indomethacin-induced enteropathy in rats. 2001 Nov 2
43 10671773 Protective effect of lafutidine against indomethacin-induced intestinal ulceration in rats: relation to capsaicin-sensitive sensory neurons. 2000 2
44 10675738 Site-specific lesion formation, inflammation and inducible nitric oxide synthase expression by indomethacin in the rat intestine. 2000 Feb 4 4
45 10818069 Effects of aspirin-like drugs on nitric oxide synthesis in rat vascular smooth muscle cells. 2000 May 1
46 11145282 Role of endothelin-converting enzyme-1 in the suppression of constitutive nitric oxide synthase in rat gastric mucosal injury by indomethacin. 2000 Nov 1
47 10192188 Activation of apoptotic caspase-3 and nitric oxide synthase-2 in gastric mucosal injury induced by indomethacin. 1999 Feb 4
48 10210150 Role of caspase-3 and nitric oxide synthase-2 in gastric mucosal injury induced by indomethacin: effect of sucralfate. 1999 Mar 3
49 10210152 Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats. 1999 Mar 3
50 10486609 Expression of NOS II and its role in experimental small bowel ulceration in rats. 1999 Sep 1