Title : Urocortin prevents indomethacin-induced small intestinal lesions in rats through activation of CRF2 receptors.

Pub. Date : 2010 Jun

PMID : 19707872






2 Functional Relationships(s)
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1 RESULTS: Indomethacin caused hemorrhagic lesions in the small intestine, accompanied by intestinal hypermotility, mucosal invasion of enterobacteria, up-regulation of inducible nitric oxide synthase (iNOS) expression, and an increase of mucosal myeloperoxidase (MPO) activity. Indomethacin nitric oxide synthase 2 Rattus norvegicus
2 RESULTS: Indomethacin caused hemorrhagic lesions in the small intestine, accompanied by intestinal hypermotility, mucosal invasion of enterobacteria, up-regulation of inducible nitric oxide synthase (iNOS) expression, and an increase of mucosal myeloperoxidase (MPO) activity. Indomethacin nitric oxide synthase 2 Rattus norvegicus