Title : Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase.

Pub. Date : 2008 Feb

PMID : 18216606






1 Functional Relationships(s)
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1 MEASUREMENTS AND MAIN RESULTS: The nonselective COX inhibitors salicylate and indomethacin enhanced the expression of iNOS in the rat gastric mucosa and exacerbated gastric injury in the presence of lipopolysaccharide, effects reversed by exogenous prostaglandin E2. Indomethacin nitric oxide synthase 2 Rattus norvegicus