Gemfibrozil

peroxisome proliferator activated receptor alpha ; Mus musculus







29 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 33514677 Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway. 2021 Mar 10 4
2 34499887 PPARα agonist exerts protective effects in podocyte injury via inhibition of the ANGPTL3 pathway. 2021 Oct 15 3
3 31963528 PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice. 2020 Jan 17 2
4 32155958 The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. 2020 Mar 6 2
5 32708962 Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice. 2020 Jul 17 7
6 31127527 Activation of Peroxisome Proliferator-Activated Receptor-α Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons. 2019 Nov 2
7 31259309 Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer's Disease via Peroxisome Proliferator-Activated Receptor α. 2019 May 18 3
8 29534628 Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system. 2018 Apr 2
9 30023335 Protective Effect of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression. 2018 Jun 1
10 30251457 PPARα-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling. 2018 Dec 1
11 27918198 PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate. 2017 Feb 2
12 28374976 Peroxisome Proliferator-Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil. 2017 Sep 5
13 30090481 Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil. 2017 Jan 1 1
14 27209701 Gemfibrozil not fenofibrate decreases systemic glucose level via PPARα. 2016 Apr 2
15 26080426 Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. 2015 Jul 7 2
16 24385052 Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity. 2014 Apr 5
17 25119429 CCR5 controls immune and metabolic functions during Toxoplasma gondii infection. 2014 1
18 22989886 Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy. 2012 Nov 9 5
19 23008696 PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists. 2012 2
20 21963672 The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice. 2011 Dec 2
21 20949026 The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice. 2010 Oct 8 1
22 19299749 Transcriptional modulation of the immune response by peroxisome proliferator-activated receptor-{alpha} agonists in autoimmune disease. 2009 Apr 1 1
23 19492148 Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes. 2009 Jun 1
24 18799592 Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. 2008 Dec 1
25 17625103 Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha. 2007 Oct 3
26 17785853 Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia. 2007 Sep 15 2
27 16764943 Peroxisome proliferator-activated receptor-alpha and retinoid X receptor agonists inhibit inflammatory responses of astrocytes. 2006 Jul 2
28 15968640 Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia. 2005 Aug 1 2
29 14709251 HIV protease inhibitor ritonavir induces lipoatrophy in male mice. 2003 Dec 1