Pub. Date : 2021 Mar 10
PMID : 33514677
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson"s disease via PPARalpha-Dependent Astrocytic GDNF Pathway. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Gemfibrozil-mediated protection of the nigrostriatal and locomotor activities in WT but not PPARalpha-/- mice from MPTP intoxication suggests that gemfibrozil needs the involvement of PPARalpha in protecting dopaminergic neurons. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | While investigating further mechanisms, we found that gemfibrozil stimulated the transcription of glial-derived neurotrophic factor (GDNF) gene in astrocytes via PPARalpha and that gemfibrozil protected nigral neurons, normalized striatal fibers and neurotransmitters, and improved locomotor activities in MPTP-intoxicated Gfaf cre mice, but not Gdnf Deltaastro mice lacking GDNF in astrocytes. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | Here, we delineate that gemfibrozil, a lipid-lowering drug, stimulates GDNF in astrocytes via peroxisome proliferator-activated receptor alpha (PPARalpha). | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |