Pub. Date : 2012 Nov 9
PMID : 22989886
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor alpha: implications for late infantile Batten disease therapy. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Because gemfibrozil and fenofibrate are known to activate peroxisome proliferator-activated receptor-alpha (PPARalpha), the role of PPARalpha in gemfibrozil- and fenofibrate-mediated up-regulation of TPP1 was investigated revealing that both drugs up-regulated TPP1 mRNA, protein, and enzymatic activity both in vitro and in vivo in wild type (WT) and PPARbeta(-/-), but not PPARalpha(-/-), mice. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | Because gemfibrozil and fenofibrate are known to activate peroxisome proliferator-activated receptor-alpha (PPARalpha), the role of PPARalpha in gemfibrozil- and fenofibrate-mediated up-regulation of TPP1 was investigated revealing that both drugs up-regulated TPP1 mRNA, protein, and enzymatic activity both in vitro and in vivo in wild type (WT) and PPARbeta(-/-), but not PPARalpha(-/-), mice. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | Because gemfibrozil and fenofibrate are known to activate peroxisome proliferator-activated receptor-alpha (PPARalpha), the role of PPARalpha in gemfibrozil- and fenofibrate-mediated up-regulation of TPP1 was investigated revealing that both drugs up-regulated TPP1 mRNA, protein, and enzymatic activity both in vitro and in vivo in wild type (WT) and PPARbeta(-/-), but not PPARalpha(-/-), mice. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |
| 5 | Because gemfibrozil and fenofibrate are known to activate peroxisome proliferator-activated receptor-alpha (PPARalpha), the role of PPARalpha in gemfibrozil- and fenofibrate-mediated up-regulation of TPP1 was investigated revealing that both drugs up-regulated TPP1 mRNA, protein, and enzymatic activity both in vitro and in vivo in wild type (WT) and PPARbeta(-/-), but not PPARalpha(-/-), mice. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Mus musculus |