Title : Peroxisome proliferator-activated receptor-alpha and retinoid X receptor agonists inhibit inflammatory responses of astrocytes.

Pub. Date : 2006 Jul

PMID : 16764943






2 Functional Relationships(s)
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1 Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Gemfibrozil peroxisome proliferator activated receptor alpha Mus musculus
2 Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells. Gemfibrozil peroxisome proliferator activated receptor alpha Mus musculus