Cisplatin

hypoxia inducible factor 1 subunit alpha ; Homo sapiens







70 Article(s)
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1 35411640 Far-infrared radiation alleviates cisplatin-induced vascular damage and impaired circulation via activation of HIF-1α. 2022 Jun 5
2 32905663 Bufalin inhibits ovarian carcinoma via targeting mTOR/HIF-α pathway. 2021 Feb 1
3 33345849 IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells. 2021 Mar 5 1
4 33413524 Correction to: microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis. 2021 Jan 7 1
5 33969609 Lysosome Fe2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells. 2021 Aug 1
6 34046349 Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway. 2021 2
7 34265288 Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers. 2021 Sep 1 1
8 34385105 Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway. 2021 Oct 4
9 34399762 Nitric oxide-releasing micelles with intelligent targeting for enhanced anti-tumor effect of cisplatin in hypoxia. 2021 Aug 16 2
10 34415232 MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel. 2021 Dec 1
11 34460078 Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1α/Mff regulation in head and neck squamous cell carcinoma. 2021 Oct 2
12 34595177 HIF1α Regulates IL17 Signaling Pathway Influencing Sensitivity of Taxane-Based Chemotherapy for Breast Cancer. 2021 1
13 34899911 The Human Positive Cofactor 4 is a Promising Chemotherapeutic Target in Lung Adenocarcinoma. 2021 1
14 35070983 Prediction of the Mechanisms by Which Quercetin Enhances Cisplatin Action in Cervical Cancer: A Network Pharmacology Study and Experimental Validation. 2021 1
15 31700155 The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance. 2020 Feb 1
16 32021271 LncRNA PVT1 Enhances Proliferation and Cisplatin Resistance via Regulating miR-194-5p/HIF1a Axis in Oral Squamous Cell Carcinoma. 2020 1
17 32194844 One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy. 2020 6
18 32328193 Self-enforcing HMGB1/NF-κB/HIF-1α Feedback Loop Promotes Cisplatin Resistance in Hepatocellular Carcinoma Cells. 2020 3
19 32432742 Autophagy related 4B, upregulated by HIF-1α, attenuates the sensitivity to cisplatin in nasopharyngeal carcinoma cells. 2020 May 3
20 32522234 HIF-1α-dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down-regulation of pro-apoptotic UNC5B and SIRT4. 2020 Jun 10 5
21 32972441 microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis. 2020 Sep 24 2
22 32978517 Oroxylin A reverses hypoxia-induced cisplatin resistance through inhibiting HIF-1α mediated XPC transcription. 2020 Nov 4
23 33239133 Aloperine can reverse the cisplatin resistance of colorectal cancer cells via suppressing the HIF-1α/ERK signaling pathway. 2020 Nov 1 1
24 33290263 Enhancer-bound Nrf2 licenses HIF-1α transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells. 2020 Dec 3 2
25 28442599 Overcoming cisplatin resistance in osteosarcoma through the miR-199a-modulated inhibition of HIF-1α. 2019 Nov 29 3
26 30867818 Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy. 2019 2
27 31088908 HIF Inactivation of p53 in Ovarian Cancer Can Be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity. 2019 Aug 1
28 31169018 The combination therapy of HIF1α inhibitor LW6 and cisplatin plays an effective role on anti-tumor function in A549 cells. 2019 Sep 2
29 29690507 Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress. 2018 Apr 21 4
30 29971135 Hypoxia exposure induced cisplatin resistance partially via activating p53 and hypoxia inducible factor-1α in non-small cell lung cancer A549 cells. 2018 Jul 6
31 30223937 HIF-1α-induced autophagy contributes to cisplatin resistance in ovarian cancer cells. 2018 Sep 1 3
32 30347860 Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance. 2018 Oct 21 1
33 30464533 Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro. 2018 3
34 28233769 Erratum: Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis. 2017 Feb 24 1
35 28543796 Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene. 2017 Oct 1
36 28790395 Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer. 2017 Aug 8 1
37 28878571 Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway. 2017 2
38 29212260 Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells. 2017 Nov 7 2
39 29276393 miR-199a modulates cisplatin resistance in ovarian cancer by targeting Hif1α. 2017 1
40 26717965 HIF-1α/MDR1 pathway confers chemoresistance to cisplatin in bladder cancer. 2016 Mar 1
41 26801746 Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism. 2016 Apr 1 34
42 27016414 MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer. 2016 Apr 26 1
43 27122375 The Role of Angiogenesis in the Persistence of Chemoresistance in Epithelial Ovarian Cancer. 2016 Nov 2
44 27473145 Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed by gambogic acid independently of HIF-1α. 2016 Sep 1
45 27492148 PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer. 2016 Aug 5 1
46 27708247 Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. 2016 Nov 1 1
47 27762347 Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis. 2016 Oct 20 1
48 27765932 Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. 2016 Dec 13 2
49 25608569 Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization. 2015 Jan 21 1
50 25748238 Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mutated lung cancer in vitro and in vivo. 2015 Feb 2