Title : microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis.

Pub. Date : 2020 Sep 24

PMID : 32972441






2 Functional Relationships(s)
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1 microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1alpha/HES1 signaling axis. Cisplatin hypoxia inducible factor 1 subunit alpha Homo sapiens
2 CONCLUSION: Overall, miR-216b enhanced the sensitivity of OS cells to cisplatin via downregulation of the JMJD2C/HIF1alpha/HES1 signaling axis, highlighting the capacity of miR-216b as an adjunct to cisplatin chemotherapy in the treatment of OS. Cisplatin hypoxia inducible factor 1 subunit alpha Homo sapiens