Pub. Date : 2016 Apr 1
PMID : 26801746
34 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
2 | By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
3 | By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
4 | By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
5 | By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
6 | By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
7 | By using two pairs of genetically matched cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines, we tested the hypothesis that downregulating hypoxia-inducible factor-1 (HIF-1), which regulates metabolic enzymes involved in glycolysis, is a promising strategy for overcoming cisplatin resistance of human ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
8 | We found that cisplatin downregulated the level of the regulatable alpha subunit of HIF-1, HIF-1alpha, in cisplatin-sensitive ovarian cancer cells through enhancing HIF-1alpha degradation but did not downregulate HIF-1alpha in their cisplatin-resistant counterparts. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
9 | We found that cisplatin downregulated the level of the regulatable alpha subunit of HIF-1, HIF-1alpha, in cisplatin-sensitive ovarian cancer cells through enhancing HIF-1alpha degradation but did not downregulate HIF-1alpha in their cisplatin-resistant counterparts. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
10 | We found that cisplatin downregulated the level of the regulatable alpha subunit of HIF-1, HIF-1alpha, in cisplatin-sensitive ovarian cancer cells through enhancing HIF-1alpha degradation but did not downregulate HIF-1alpha in their cisplatin-resistant counterparts. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
11 | We found that cisplatin downregulated the level of the regulatable alpha subunit of HIF-1, HIF-1alpha, in cisplatin-sensitive ovarian cancer cells through enhancing HIF-1alpha degradation but did not downregulate HIF-1alpha in their cisplatin-resistant counterparts. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
12 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
13 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
14 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
15 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
16 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
17 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
18 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
19 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
20 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
21 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
22 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
23 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
24 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
25 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
26 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
27 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
28 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
29 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
30 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
31 | Overexpression of a degradation-resistant HIF-1alpha (HIF-1alpha DeltaODD) reduced cisplatin-induced apoptosis in cisplatin-sensitive cells, whereas genetic knockdown of HIF-1alpha or pharmacological promotion of HIF-1alpha degradation enhanced response to cisplatin in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
32 | We further demonstrated that knockdown of HIF-1alpha improved the response of cisplatin-resistant ovarian cancer cells to cisplatin by redirecting the aerobic glycolysis in the resistant cancer cells toward mitochondrial oxidative phosphorylation, leading to cell death through overproduction of reactive oxygen species. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
33 | We further demonstrated that knockdown of HIF-1alpha improved the response of cisplatin-resistant ovarian cancer cells to cisplatin by redirecting the aerobic glycolysis in the resistant cancer cells toward mitochondrial oxidative phosphorylation, leading to cell death through overproduction of reactive oxygen species. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
34 | Our findings suggest that the HIF-1alpha-regulated cancer metabolism pathway could be a novel target for overcoming cisplatin resistance in ovarian cancer. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |