Title : Enhancer-bound Nrf2 licenses HIF-1α transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells.

Pub. Date : 2020 Dec 3

PMID : 33290263






2 Functional Relationships(s)
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Protein Name
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1 Enhancer-bound Nrf2 licenses HIF-1alpha transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells. Cisplatin hypoxia inducible factor 1 subunit alpha Homo sapiens
2 As a result, Nrf2-dependent transcription counteracts HIF-1alpha degradation under mild hypoxia condition, leading to preferential cisplatin-resistance in HepG2/DDP cells. Cisplatin hypoxia inducible factor 1 subunit alpha Homo sapiens