Indomethacin

prostaglandin-endoperoxide synthase 2 ; Homo sapiens







88 Article(s)
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51 14517215 Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. 2003 Dec 12 1
52 11809691 Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. 2002 Jan 15 2
53 11858641 Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2). 2002 Jan 2
54 11867761 Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication. 2002 Mar 19 1
55 11898476 Hemicrania continua: recent treatment strategies and diagnostic evaluation. 2002 Mar 1
56 11906281 Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. 2002 Mar 28 2
57 12135387 Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis. 2002 Jul 30 5
58 12181161 Ca2+- and PKC-dependent stimulation of PGE2 synthesis by deoxycholic acid in human colonic fibroblasts. 2002 Sep 1
59 12324457 Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. 2002 Nov 29 1
60 12398900 On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1. 2002 Oct 25 2
61 12485493 [Delayed rectifier K(+) channel regulated by cyclooxygenase-2 in human gastric cancer cell]. 2002 Sep 1
62 11237475 Indomethacin increases 15-PGDH mRNA expression in HL60 cells differentiated by PMA. 2001 Feb 1
63 11310828 Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells. 2001 Mar 1
64 11567657 Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves. 2001 Sep 21 1
65 10657949 Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. 2000 Feb 2
66 10956194 Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. 2000 Jul 27 4
67 11034610 Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. 2000 Oct 16 1
68 11035215 The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat. 2000 Aug 1
69 11192938 Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. 2000 Dec 1
70 10027864 Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators. 1999 Mar 1
71 10091284 [Preferential COX-2 inhibition: its clinical relevance for gastrointestinal non-steroidal anti-inflammatory rheumatic drug toxicity]. 1999 Jan 1
72 10388637 The influence of indomethacin on the metabolism and cytokine secretion of human aneurysmal aorta. 1999 Jul 1
73 10419480 Rapid kinetics of tyrosyl radical formation and heme redox state changes in prostaglandin H synthase-1 and -2. 1999 Jul 30 2
74 10477832 PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. 1999 Aug 25 2
75 10531359 Role of the cyclic AMP-protein kinase A pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2. 1999 Oct 29 1
76 10594327 Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. 1999 Nov 3 1
77 9593932 Effects of anoxic stress on prostaglandin H synthase isoforms in piglet brain. 1998 May 15 1
78 9627083 Down-regulation of interleukin-1beta production and PGE2 accumulation by an indomethacin-phenylalanine derivative in human monocytes. 1998 1
79 9872498 Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development. 1998 1
80 9016346 Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs. 1997 Jan 3
81 9351974 The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs. 1997 Nov 5
82 9369945 Regulation of human monocyte matrix metalloproteinases by SPARC. 1997 Dec 1
83 8631960 The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen. 1996 Feb 16 2
84 8718891 Inhibitor-induced changes in the intrinsic fluorescence of human cyclooxygenase-2. 1996 Aug 20 1
85 8798446 Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts. An in vitro model for connective tissue inflammation. 1996 Sep 13 2
86 8831731 Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. 1996 Oct 11 2
87 8894718 Prostaglandin production via induction of cyclooxygenase-2 by human gingival fibroblasts stimulated with lipopolysaccharides. 1996 Oct 1
88 7996488 Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. 1994 Dec 1