Title : Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.

Pub. Date : 1996 Oct 11

PMID : 8831731






2 Functional Relationships(s)
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1 Reversible inhibition of cellular CHO [hPGHS-1] and CHO [hPGHS-2] was observed with the nonselective NSAIDs ibuprofen and indomethacin, whereas inhibition by the selective PGHS-2 inhibitor DuP-697 was reversible against hPGHS-1 but irreversible against hPGHS-2. Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Reversible inhibition of cellular CHO [hPGHS-1] and CHO [hPGHS-2] was observed with the nonselective NSAIDs ibuprofen and indomethacin, whereas inhibition by the selective PGHS-2 inhibitor DuP-697 was reversible against hPGHS-1 but irreversible against hPGHS-2. Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens