Cisplatin

signal transducer and activator of transcription 3 ; Homo sapiens







135 Article(s)
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101 25586740 MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-β/Smad2/STAT3/STAT5 pathway. 2015 May 1
102 25843419 Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carcinoma (ESCC) cells via suppression of PI3K/AKT and Stat3 pathways. 2015 Jun 1 1
103 25867391 Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro. 2015 Mar 30 2
104 23661500 SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer. 2014 Oct 2
105 24659656 Suppression of STAT3 by chemically modified siRNAs increases the chemotherapeutic sensitivity of parental and cisplatin-resistant non-small cell lung cancer cells. 2014 Jan-Mar 3
106 24944268 Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation. 2014 Aug 15 1
107 25213670 Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC. 2014 Nov 2
108 25514838 WP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axis. 2014 Dec 17 1
109 23149124 Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFα- and NK cytotoxicity. 2013 Feb 15 1
110 23319321 Protective effects of ADAM8 against cisplatin-mediated apoptosis in non-small-cell lung cancer. 2013 Jan 2
111 23426872 Regulation of AKT gene expression by cisplatin. 2013 Mar 3
112 23427943 Simultaneous suppression of Src and signal transducer and activator of transcription 3 inhibits the growth of epithelial ovarian cancer cells. 2013 Jul 1
113 23436796 Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment. 2013 Apr 15 1
114 23526220 Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway. 2013 Aug 3
115 23546174 Overexpression of AKT decreases the chemosensitivity of gastric cancer cells to cisplatin in vitro and in vivo. 2013 May 3
116 23665025 Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells. 2013 May 31 3
117 23962558 Abrogation of constitutive Stat3 activity circumvents cisplatin resistant ovarian cancer. 2013 Dec 1 7
118 23969971 Early responses of the STAT3 pathway to platinum drugs are associated with cisplatin resistance in epithelial ovarian cancer. 2013 Aug 7
119 24083752 AZD1480 can inhibit the biological behavior of ovarian cancer SKOV3 cells in vitro. 2013 1
120 21875334 A potent oncolytic adenovirus selectively blocks the STAT3 signaling pathway and potentiates cisplatin antitumor activity in ovarian cancer. 2012 Jan 1
121 21909139 Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells. 2012 May 3 6
122 22104727 Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells. 2012 Feb 28 1
123 22280969 Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3). 2012 Jan 26 3
124 22847808 Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma. 2012 Sep 15 2
125 22961117 Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. 2012 Nov 2
126 21885917 HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. 2011 Nov 1 1
127 20127005 Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. 2010 Mar 5
128 19427998 STI571 sensitizes breast cancer cells to 5-fluorouracil, cisplatin and camptothecin in a cell type-specific manner. 2009 Aug 1 1
129 19623660 Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. 2009 Nov 1 1
130 18196976 NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. 2008 Jan 1 1
131 18059167 Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma. 2007 Dec 4
132 15592503 In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. 2005 Feb 3 3
133 15643501 Overexpression of constitutive signal transducer and activator of transcription 3 mRNA in cisplatin-resistant human non-small cell lung cancer cells. 2005 Feb 3
134 15010843 Modulation of Janus kinase 2 by cisplatin in cancer cells. 2004 Apr 1
135 10978511 Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells. 2000 Sep 7 4