Pub. Date : 2013 Mar
PMID : 23426872
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study demonstrated the role of reactive oxygen species (ROS) in the induction of AKT regulation by cisplatin through the activation of JAK2/STAT3 at the transcriptional level in colon cancer cells. | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | HCT-116 cells treated with cisplatin exhibited increased JAK2 and STAT3 activities. | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | The JAK2/STAT3 pathway was also shown to mediate AKT expression and represents a potential target for overcoming cisplatin resistance in human tumors. | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |