Pub. Date : 2010 Mar
PMID : 20127005
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | We found that high expression levels of Stat3 and Notch1 were closely associated with cisplatin resistance respectively (P=0.014, P=0.000). | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | In addition, cisplatin resistance of HNSCC was decreased after inhibition of Stat3 or Notch signaling in vitro. | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Our results provide first evidence that both high Stat3 and Notch1 expression are associated with cisplatin resistance in HNSCC patients, supporting the hypothesis that co-activation of Stat3 and Notch1 by their crosstalk induces the reprogrammed survival pathways in HNSCC responding to chemotherapy. | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Our results provide first evidence that both high Stat3 and Notch1 expression are associated with cisplatin resistance in HNSCC patients, supporting the hypothesis that co-activation of Stat3 and Notch1 by their crosstalk induces the reprogrammed survival pathways in HNSCC responding to chemotherapy. | Cisplatin | signal transducer and activator of transcription 3 | Homo sapiens |